Penetration of didanosine in semen of HIV-1-infected men
نویسندگان
چکیده
منابع مشابه
Semen alterations in HIV-1 infected men.
BACKGROUND Couples in whom the man is infected by human immunodeficiency virus (HIV) increasingly request assisted reproductive technology (ART) to allow safe procreation. Semen quality is critical in such situations. METHODS Semen characteristics were evaluated in 189 HIV-infected men requesting ART. At the time of semen analysis all men were healthy and 177 were receiving anti-retroviral th...
متن کاملAntiretroviral drug concentrations in semen of HIV-1 infected men.
Because semen is a major vehicle for the sexual transmission of HIV-1, control of viral replication within the sanctuary of the male genital tract should be a goal of antiretroviral therapy. Local immune responses, virus specific factors, and the degree of viral and cellular trafficking all appear to be important in controlling viral replication and evolution. However, the most important factor...
متن کاملPharmacokinetics of raltegravir in the semen of HIV-infected men.
BACKGROUND We sought to determine the pharmacokinetic disposition of raltegravir in the blood and seminal plasma of HIV-infected men. METHODS We conducted a pharmacokinetic study using a staggered sampling approach. A total of 16 HIV-infected men receiving raltegravir-based therapy were recruited into the study. Each participant provided six blood plasma and six seminal plasma samples for qua...
متن کاملGynaecomastia in HIV-infected men on highly active antiretroviral therapy: association with efavirenz and didanosine treatment.
BACKGROUND Gynaecomastia has been described in HIV-infected men undergoing highly active antiretroviral therapy (HAART). However, there are insufficient data on the relationship between gynaecomastia and any specific antiretroviral drug and hormone abnormality. OBJECTIVE To assess the frequency of gynaecomastia in HIV-infected men receiving HAART and its association with antiretroviral drugs ...
متن کاملSemen characteristics in HIV-1 positive men and the effect of semen washing.
We have undertaken an analysis of semen from HIV infected men with regard to sperm counts and motility, non-spermatozoal cells, and viral nucleic acid. Regression analysis showed that sperm concentration and motility were positively associated with blood CD4 cell count. By contrast, non-spermatozoal cell concentration (round cells) was inversely related to CD4 count. Extracellular HIV RNA was d...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2006
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkl111